![]() ![]() ![]() As this journal undergoes an expansion in focus and nomenclature from cerebrospinal fluid (CSF) into all barriers of the central nervous system (CNS), this review traces the history of both the blood-CSF and blood-brain barriers from as early as it was possible to find references, to the time when modern concepts were established at the beginning of the 20 th century.Ī large amount of information available on the barriers of the brain, especially in development, remains a tangled and somewhat controversial matter, despite research in the field going back centuries. Notwithstanding this, the insight that can be gained from the study of the beginnings of a subject can prove important in the understanding of work more recently completed. The scientific method is so fundamental to modern science that some philosophers consider earlier investigations as 'pre-science'. While empirical investigations have been described by many since the time of Aristotle and scientific methods have been employed since the Middle Ages, the beginnings of modern science are generally accepted to have originated during the 'scientific revolution' of the 16 th and 17 th centuries in Europe. It is possible for the astute reader to follow the background of any subject through the many important surviving texts from the classical and ancient world. Tracing the exact origins of modern science can be a difficult but rewarding pursuit. ![]()
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